Newly developed approach shows promise in silencing HIV infection
The HIV virus gets integrated into the infected person's genetic coding and establishes a constant dormant infection, creating a big treatment challenge. Because of this, current ART medications fail to cure the virus and when someone stops the drug, the virus almost always begins to multiply and wreak havoc. Drug resistance is also a public health issue with ART medications. Being able to induce a sustained HIV remission free of ART is an important goal for HIV treatment."We are the first to show that human BRD4 protein and its associated machinery can be harnessed to suppress dormant HIV," said senior author Haitao Hu, UTMB assistant professor in the department of microbiology and immunology. "Our findings are exciting because of they not only improve our understanding of the biology of HIV epigenetic regulation, they also present a promising approach for the development of probes and/or therapeutic agents for HIV silencing, hopefully leading to cure of the virus eventually."